"SIRT7" Related Products

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Recombinant Human Sirtuin 7, His-tagged

Cat. No. : SIRT7-4884H
Product Overview : Full-length recombinant human SIRT7 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Description : SIRT7 is a member of the class IV of sirtuin family of proteins which are homologs to the yeast Sir2 protein and play a role in cell differentiation, proliferation, apoptosis, metabolism, and senescence. SIRT7 associates with active rRNA genes and histones. Overexpression of SIRT7 increases pol I-mediated transcription whereas knockdown of SIRT7 or inhibition of its catalytic activity results in decreased association of pol I with rDNA and reduced pol I transcription.
Applications : SIRT Assay
Molecular Weight : 46 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25 % glycerol.
Specific Activity : 140 RLU/min/mg
Purity : > 95 %
Concentration : 0.1 ug/ul
Sequences : Full length
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Signaling events mediated by HDAC Class I; Signaling events mediated by HDAC Class III
Gene Name : SIRT7 sirtuin 7 [ Homo sapiens ]
Official Symbol : SIRT7
Synonyms : SIRT7; sirtuin 7; SIR2L7; MGC126840; MGC126842; NAD-dependent deacetylase sirtuin-7; sirtuin type 7; SIR2-like protein 7; sir2-related protein type 7; silent mating type information regulation 2, S.cerevisiae, homolog 7; EC 3.5.1.-; sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 7
Gene ID : 51547
mRNA Refseq : NM_016538
Protein Refseq : NP_057622
MIM : 606212
UniProt ID : Q9NRC8
Chromosome Location : 17q25.3
Function : NAD binding; hydrolase activity; metal ion binding; protein binding; zinc ion binding

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