| Cat. No. : |
SMAD2-1093H |
| Product Overview : |
Recombinant full-length human SMAD2 was expressed in E. coli cells using an N-terminal GST tag. |
| Description : |
SMAD2 is an intracellular mediator of TGFβ family and activin type 1 receptor. SMAD2 mediate TGFβ signaling to regulate cell growth and differentiation. SMAD2 is released from cytoplasmic retention by TGFβ receptor-mediated phosphorylation. The phosphorylated SMAD2 then forms a heterodimeric complex with SMAD4, and this complex translocates from cytoplasm into nucleus. |
| Applications : |
Kinase Assay; Western Blot |
| Molecular Weight : |
90 kDa |
| Expression System : |
E. coli |
| Species : |
Human |
| Form : |
Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25 % glycerol. |
| Purity : |
> 90 % |
| Concentration : |
0.2 ug/ul |
| Sequences : |
Full-lengt h |
| Storage : |
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Pathways : |
Adherens junction; Alpha6-Beta4 Integrin Signaling Pathway; Cell cycle; Chagas disease (American trypanosomiasis); Colorectal cancer; EGFR1 Signaling Pathway; Endocytosis; Glypican 1 network; HTLV-I infection; Pancreatic cancer; Pathways in cancer; Regulation of cytoplasmic and nuclear SMAD2/3 signaling; Regulation of nuclear SMAD2/3 signaling; Signaling by TGF beta; TGF Beta Signaling Pathway; Wnt signaling pathway |
| PDBrendering based on 1dev. : |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.