Recombinant Human SMAD Family Member 2, GST-tagged
Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.
Cat. No. : | SMAD2-1093H |
Product Overview : | Recombinant full-length human SMAD2 was expressed in E. coli cells using an N-terminal GST tag. |
Description : | SMAD2 is an intracellular mediator of TGFβ family and activin type 1 receptor. SMAD2 mediate TGFβ signaling to regulate cell growth and differentiation. SMAD2 is released from cytoplasmic retention by TGFβ receptor-mediated phosphorylation. The phosphorylated SMAD2 then forms a heterodimeric complex with SMAD4, and this complex translocates from cytoplasm into nucleus. |
Applications : | Kinase Assay; Western Blot |
Molecular Weight : | 90 kDa |
Expression System : | E. coli |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25 % glycerol. |
Purity : | > 90 % |
Concentration : | 0.2 ug/ul |
Sequences : | Full-lengt h |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | Adherens junction; Alpha6-Beta4 Integrin Signaling Pathway; Cell cycle; Chagas disease (American trypanosomiasis); Colorectal cancer; EGFR1 Signaling Pathway; Endocytosis; Glypican 1 network; HTLV-I infection; Pancreatic cancer; Pathways in cancer; Regulation of cytoplasmic and nuclear SMAD2/3 signaling; Regulation of nuclear SMAD2/3 signaling; Signaling by TGF beta; TGF Beta Signaling Pathway; Wnt signaling pathway |
PDBrendering based on 1dev. : |
![]() |
Gene Name : | SMAD2 SMAD family member 2 [ Homo sapiens ] |
Official Symbol : | SMAD2 |
Synonyms : | SMAD2; SMAD family member 2; JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440; mothers against decapentaplegic homolog 2; MAD homolog 2; OTTHUMP00000163489; mother against DPP homolog 2; Sma- and Mad-related protein 2; SMAD, mothers against DPP homolog 2; MAD, mothers against decapentaplegic homolog 2 (Drosophila); SMAD, mothers against DPP homolog 2 (Drosophila); Mothers against decapentaplegic homolog 2; Mothers against DPP homolog 2; Mad-related protein 2 |
Gene ID : | 4087 |
mRNA Refseq : | NM_001003652 |
Protein Refseq : | NP_001003652 |
MIM : | 601366 |
UniProt ID : | Q15796 |
Chromosome Location : | 18q21 |
Function : | R-SMAD binding; co-SMAD binding; double-stranded DNA binding; protein binding; transcription activator activity; transcription factor activity; transcription factor binding; transforming growth factor beta receptor; type I transforming growth factor beta receptor binding; ubiquitin protein ligase binding; contributes to DNA binding; I-SMAD binding; chromatin binding; phosphatase binding; sequence-specific DNA binding transcription factor activity |
◆ Recombinant Protein
SMAD2-1915H | Recombinant Human SMAD2 Protein, MYC/DDK-tagged | +Inquiry |
Smad2-5950M | Recombinant Mouse Smad2 Protein, Myc/DDK-tagged | +Inquiry |
Smad2-307M | Recombinant Mouse Smad2 Protein, His-tagged | +Inquiry |
SMAD2-306H | Recombinant Human SMAD2 Protein, His-tagged | +Inquiry |
SMAD2-4398H | Recombinant Human SMAD2 protein, His-SUMO-tagged | +Inquiry |
|
◆ Lysates
SMAD2-001MCL | Recombinant Mouse SMAD2 cell lysate | +Inquiry |
|
Easy access to products and services you need from our library via powerful searching tools.
Copyright © 2022 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy