| Cat. No.: | SMAD5-1096H |
| Product Overview: | Recombinant full-length human SMAD5 was expressed in E. coli cells using an N-terminal GST tag. |
| Description: | SMAD5 is a member of the SMAD family and mediates signaling by the transforming growth factor-beta (TGFβ) superfamily and related ligands. SMAD5 plays a critical role in the signaling pathway by which TGFβ inhibits the proliferation of human hematopoietic progenitor cells. SMAD5 is up-regulated in gastric epithelial cells during the infection of the pathogen Helicobacter pylori and it mediates apoptosis of gastric epithelial cells induced by H. pylori infection. In mature human B cells, bone morphogenetic protein 6 (BMP-6) inhibits cell growth and rapidly induces phosphorylation of SMADs 5 and 8. |
| Applications: | Kinase Assay; Western Blot |
| Molecular Weight: | 82 kDa |
| Species: | Human |
| Form: | Recombinant protein stored in 50 mM Tris-HCL, pH 7.5, 150 mM NaCl, 0.1 mM PMSF, 0.25 mM DTT, 25 % glycerol. |
| Purity: | > 90 % |
| Concentration: | 0.2 ug/ul |
| Sequences: | Full-length |
| Storage: | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Pathways: | ALK1 signaling events; ALK2 signaling events; BMP receptor signaling; Id Signaling Pathway; Signaling by BMP; TGF Beta Signaling Pathway; TGF-beta signaling pathway |
| Gene Name: | SMAD5 SMAD family member 5 [ Homo sapiens ] |
| Official Symbol: | SMAD5 |
| Synonyms: | SMAD5; SMAD family member 5; DWFC; JV5-1; MADH5; DKFZp781C1895; DKFZp781O1323; MAD, mothers against decapentaplegic homolog 5 (Drosophila); SMAD, mothers against DPP homolog 5 (Drosophila); Dwfc; Mothers against decapentaplegic homolog 5; MAD homolog 5; Mothers against DPP homolog 5; Smad5; hSmad5; OTTHUMP00000223331; mothers against decapentaplegic, drosophila, homolog of, 5; SMA- and MAD-related protein 5; SMAD, mothers against DPP homolog 5; SMAD 5 |
| Gene ID: | 4090 |
| mRNA Refseq: | NM_005903 |
| Protein Refseq: | NP_005894 |
| MIM: | 603110 |
| UniProt ID: | Q99717 |
| Chromosome Location: | 5q31 |
| Function: | protein binding; receptor signaling protein activity; transcription activator activity; transcription factor activity; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
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