Recombinant Human SMAD Family Member 5, GST-tagged

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Recombinant Human SMAD Family Member 5, GST-tagged

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Cat. No. : SMAD5-1096H
Product Overview : Recombinant full-length human SMAD5 was expressed in E. coli cells using an N-terminal GST tag.
Description : SMAD5 is a member of the SMAD family and mediates signaling by the transforming growth factor-beta (TGFβ) superfamily and related ligands. SMAD5 plays a critical role in the signaling pathway by which TGFβ inhibits the proliferation of human hematopoietic progenitor cells. SMAD5 is up-regulated in gastric epithelial cells during the infection of the pathogen Helicobacter pylori and it mediates apoptosis of gastric epithelial cells induced by H. pylori infection. In mature human B cells, bone morphogenetic protein 6 (BMP-6) inhibits cell growth and rapidly induces phosphorylation of SMADs 5 and 8.
Applications : Kinase Assay; Western Blot
Molecular Weight : 82 kDa
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCL, pH 7.5, 150 mM NaCl, 0.1 mM PMSF, 0.25 mM DTT, 25 % glycerol.
Purity : > 90 %
Concentration : 0.2 ug/ul
Sequences : Full-lengt h
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : ALK1 signaling events; ALK2 signaling events; BMP receptor signaling; Id Signaling Pathway; Signaling by BMP; TGF Beta Signaling Pathway; TGF-beta signaling pathway
Gene Name : SMAD5 SMAD family member 5 [ Homo sapiens ]
Official Symbol : SMAD5
Synonyms : SMAD5; SMAD family member 5; DWFC; JV5-1; MADH5; DKFZp781C1895; DKFZp781O1323; MAD, mothers against decapentaplegic homolog 5 (Drosophila); SMAD, mothers against DPP homolog 5 (Drosophila); Dwfc; Mothers against decapentaplegic homolog 5; MAD homolog 5; Mothers against DPP homolog 5; Smad5; hSmad5; OTTHUMP00000223331; mothers against decapentaplegic, drosophila, homolog of, 5; SMA- and MAD-related protein 5; SMAD, mothers against DPP homolog 5; SMAD 5
Gene ID : 4090
mRNA Refseq : NM_005903
Protein Refseq : NP_005894
MIM : 603110
UniProt ID : Q99717
Chromosome Location : 5q31
Function : protein binding; receptor signaling protein activity; transcription activator activity; transcription factor activity; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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