| Cat. No. : |
SMAD5-1096H |
| Product Overview : |
Recombinant full-length human SMAD5 was expressed in E. coli cells using an N-terminal GST tag. |
| Description : |
SMAD5 is a member of the SMAD family and mediates signaling by the transforming growth factor-beta (TGFβ) superfamily and related ligands. SMAD5 plays a critical role in the signaling pathway by which TGFβ inhibits the proliferation of human hematopoietic progenitor cells. SMAD5 is up-regulated in gastric epithelial cells during the infection of the pathogen Helicobacter pylori and it mediates apoptosis of gastric epithelial cells induced by H. pylori infection. In mature human B cells, bone morphogenetic protein 6 (BMP-6) inhibits cell growth and rapidly induces phosphorylation of SMADs 5 and 8. |
| Applications : |
Kinase Assay; Western Blot |
| Molecular Weight : |
82 kDa |
| Species : |
Human |
| Form : |
Recombinant protein stored in 50 mM Tris-HCL, pH 7.5, 150 mM NaCl, 0.1 mM PMSF, 0.25 mM DTT, 25 % glycerol. |
| Purity : |
> 90 % |
| Concentration : |
0.2 ug/ul |
| Sequences : |
Full-lengt h |
| Storage : |
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Pathways : |
ALK1 signaling events; ALK2 signaling events; BMP receptor signaling; Id Signaling Pathway; Signaling by BMP; TGF Beta Signaling Pathway; TGF-beta signaling pathway |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.