"YWHAE" Related Products


Recombinant Human Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Epsilon Polypeptide

Cat. No.: YWHAE-4896H
Product Overview: Recombinant full-length human tag-free YWHAE was expressed in E. coli.
Description: YWHAE, also known as tyrosine 3-monooxygenase/ tryptophan 5-monooxygenase activation protein is a member of the 14-3-3 family. YWHAE has been reported to be involved in heat shock transcription factor 1 (HSF1) and extracellular signal regulated protein kinase (ERK) pathways. YWHAE interaction with the deubiquitinating enzyme UBPY, also known as USP8, regulates cargo sorting and membrane traffic at early endosomes. Association of YWHAE, HSF1 with ERK during heat shock may modulate the amplitude of the response and control the termination of HSP expression on resumption of growth conditions.
Applications: Western Blot
Molecular Weight: 30kDa
Expression System: E.coli
Species: Human
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity: >90 %
Concentration: 0.2ug/ul
Sequences: Full-length
Storage: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: Cell cycle; Signalling by NGF; Alpha6-Beta4 Integrin Signaling Pathway; Calcium Regulation in the Cardiac Cell; Cell death signalling via NRAGE; Centrosome maturation; Class I PI3K signaling events mediated by Akt; ErbB1 downstream signaling; FoxO family signaling; G2/M Transition; IGF1 pathway; Insulin-mediated glucose transport; LKB1 signaling events; Lissencephaly gene (LIS1) in neuronal migration and development; Loss of Nlp from mitotic centrosomes
Gene Name: YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [ Homo sapiens ]
Official Symbol: YWHAE
Synonyms: YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; MDS; MDCR; KCIP-1; 14-3-3E; 14-3-3 Epsilon; FLJ45465; 14-3-3 epsilon; mitochondrial import stimulation factor L subunit; protein kinase C inhibitor protein-1; tyrosine 3/tryptophan 5 -monooxygenase activation protein; epsilon polypeptide
Gene ID: 7531
mRNA Refseq: NM_006761
Protein Refseq: NP_006752
MIM: 605066
UniProt ID: P62258
Chromosome Location: 17p13.3
Function: enzyme binding; protein domain specific binding; histone deacetylase binding; phosphoprotein binding; protein binding

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