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Recombinant Human Decapping Enzyme, Scavenger, His-tagged

Cat. No.: DCPS-1680H
Product Overview: Recombinant human DCPS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Description: DCPS, also known as scavenger mRNA-decapping enzyme, belongs to the HIT family. It is necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. A scavenger decapping enzyme, DcpS was shown to hydrolyze the residual m7GpppN cap structure after the complete 3?–5? degradation of the mRNA by the exosome. DcpS releases m7GMP and is unable to cleave cap structures attached to a long RNA chain.
Concentration: 0.5 mg/ml
Source: Human
Host: E.coli
Form: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, with 20% glycerol and 1mM DTT.
Purity: > 90% by SDS - PAGE
Sequence: 1-337 amino acids: MGSSHHHHHH SSGLVPRGSH MADAAPQLGK RKRELDVEEA HAASTEEKEA GVGNGTCAPV RLPFSGFRLQ KVLRESARDK IIFLHGKVNE ASGDGDGEDA VVILEKTPFQ VEQVAQLLTG SPELQLQFSN DIYSTYHLFP PRQLNDVKTT VVYPATEKHL QKYLRQDLRL IRETGDDYRN ITLPHLESQS LSIQWVYNIL DKKAEADRIV FENPD
Molecular Mass: 40.8 kDa
Applications: SDS PAGE
Storage: Store at 4 deg C for short term storage. Aliquot and store at -20 deg C or -70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name: DCPS decapping enzyme, scavenger [ Homo sapiens ]
Official Symbol: DCPS
Synonyms: DCPS; HSL1; HINT-5; HSPC015; decapping enzyme, scavenger; scavenger mRNA-decapping enzyme DcpS; DCS-1; OTTHUMP00000231113; mRNA decapping enzyme; heat shock-like protein 1; histidine triad protein member 5; hint-related 7meGMP-directed hydrolase; homolog of C. elegans 7meGMP-directed hydrolase dcs-1; EC 3.
Gene ID: 28960
mRNA Refseq: NM_014026
Protein Refseq: NP_054745
MIM: 610534
UniProt ID: Q96C86
Chromosome Location: 11q24.2
Pathway: Deadenylation-dependent mRNA decay; Metabolism of RNA; Metabolism of Mrna; RNA degradation; mRNA Decay by 3" to 5" Exoribonuclease
Function: hydrolase activity; protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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