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Recombinant Mouse Ddr1, His-tagged

Cat. No.: Ddr1-1150M
Product Overview: A DNA sequence encoding the extracellular domain of mouse Ddr1 isoform 1 ( Q03146-1 ) ( Met 1 - Thr 414 ) was expressed, with a C-terminal polyhistidine tag.
Description: Ddr1 is a single-pass type I membrane protein. It belongs to the protein kinase superfamily and Insulin receptor subfamily. Ddr1 contains one F5/8 type C domain and one protein kinase domain. Ddr1 is expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Ddr1 is abundantly expressed in breast carcinoma cell lines. Ddr1 regulates cell adhesion and a broad range of cell behavior. Ddr1 plays an important role as a collagen receptor, mediating intimal thickening after vascular injury.
Source: Mouse
Host: Human Cells
Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Purity: > 95 % as determined by SDS-PAGE
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Stability: Samples are stable for up to twelve months from date of receipt at -70°C.
Predicted N terminal: Asp 20
Molecular Mass: The secreted recombinant mouse Ddr1 comprises 406 amino acids and has a calculated molecular mass of 45.4 kDa. As a result of glycosylation, the apparent molecular mass of rm Ddr1 is approximately 50 kDa in SDS-PAGE under reducing conditions.
Application: SDS-PAGE
Reconstitution: Detailed reconstitution instructions are sent along with the products.
Storage: Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name: Ddr1 discoidin domain receptor family, member 1 [ Mus musculus ]
Official Symbol: Ddr1
Synonyms: Ddr1; discoidin domain receptor family, member 1; Cak; Nep; PTK3A; CD167a; AI323681; 6030432F18; Epithelial discoidin domain-containing receptor 1; Epithelial discoidin domain receptor 1; EC 2.7.10.1; CD167 antigen-like family member A; Cell adhesion kinase; Discoidin receptor tyrosine kinase; Protein-tyrosine kinase MPK-6; Tyrosine kinase DDR; Tyrosine-protein kinase CAK; Eddr1; Mpk6
Gene ID: 12305
mRNA Refseq: NM_007584
Protein Refseq: NP_031610
MIM: 99216
UniProt ID: Q03164
Chromosome Location: 17
Function: ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein tyrosine kinase activity; receptor activity; transferase activity; transferase activity, transferring phosphorus-containing groups; transmembrane receptor protein tyrosine kinase activity

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