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Recombinant Human Interleukin-1 alpha

Cat. No.: IL1A -01H
Product Overview: Recombinant Human Interleukin-1 alpha produced in E.coli is a single non-glycosylated polypeptide chain containing 159 amino acids and having a molecular mass of approximately 18 KDa.
Description: IL-1 alpha is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1beta is a secreted cytokine, IL-1alpha is predominantly a cell-associated cytokine.
Purity: >97% by SDS-PAGE and HPLC analyses.
Formulation: Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution in PBS, pH 7.5.
Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant stimulation of murine D10S cells is less then 0.001 ng/ml, corresponding to a Specific Activity of 1 x 109IU/mg.
Endotoxin: Less than 1EU/mg of rHuIL-1α as determined by LAL method.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at<-20°C. Further dilutions should be made in appropriate buffered solutions.
Storage: This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Gene Name: IL1A
Synonyms: IL-1A; IL1; IL1-ALPHA; IL1F1; IL1A (IL1F1); hematopoietin-1; preinterleukin 1 alpha; pro-interleukin-1-alpha; IL-1 alpha; IL-1α; IL1A (IL1F1); Interleukin-1 alpha precursor; interleukin 1, alpha; IL1AIL-1A; IL1; IL1-ALPHA; IL1F1; IL1A(IL1F1); hematopoietin-1; preinterleukin 1 alpha; pro-interleukin-1-alpha; IL-1 alpha; IL-1α; IL1A(IL1F1); Interleukin-1 alpha precursor; interleukin 1, alpha; IL1A
Gene ID: 3552
mRNA Refseq: NM_000575.3
Protein Refseq: NP_000566.3
MIM: 147760
UniProt ID: P01583
Chromosome Location: 2q14
Pathway: Apoptosis, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway, Type I diabetes mellitus.
Function: interleukin-1 receptor binding, protein binding, signal transducer activity.

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