Recombinant Human TSLP
Cat.No. : | TSLP-8307H |
Product Overview : | A DNA sequence encoding Human TSLP was expressed. |
- Specification
- Gene Information
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Description : | Thymic stromal lymphopoietin (TSLP) is an IL-7-like epithelial cell-derived cytokine that supports differentiation and long-term growth of B cells. It is expressed in the heart, liver, testis and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5 but uses kinases other than the JAKs for activation. It activates DCs primed na?ve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFα) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation. TSLP prohibits apoptosis and stimulates growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells. |
Species : | Human |
Form : | This recombinant protein was 0.2 μm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives. |
Molecular Mass : | The predicted molecular weight of Recombinant Human TSLP is Mr 15 kDa. |
AA Sequence : | myd ftncdfekik aaylstiskd litymsgtks tefnntvscs nrphclteiq sltfnptagc aslakemfam ktkaalaiwc pgysetqina tqamkkrrkr kvttnkcleq vsqlqglwrr fnrpllkqq |
Endotoxin : | <1.0 eu/μg as determined by the lal>1.0> |
Purity : | >95% by SDS-PAGE and analyzed by silver stain. |
Storage : | The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Gene Name : | TSLP thymic stromal lymphopoietin [ Homo sapiens ] |
Official Symbol : | TSLP |
Synonyms : | TSLP; thymic stromal lymphopoietin; |
Gene ID : | 85480 |
mRNA Refseq : | NM_033035 |
Protein Refseq : | NP_149024 |
MIM : | 607003 |
UniProt ID : | Q969D9 |
Chromosome Location : | 5q22.1 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; |
Function : | cytokine activity; |
Products Types
◆ Recombinant Protein | ||
Tslp-501M | Recombinant Mouse Tslp Protein, His&SUMO-tagged | +Inquiry |
TSLP-499H | Recombinant Human TSLP Protein, His-tagged | +Inquiry |
Tslp-01M | Recombinant Mouse Tslp Protein, His-tagged | +Inquiry |
TSLP-139H | Active Recombinant Human TSLP Protein, His-tagged, R127A, R130A | +Inquiry |
TSLP-138H | Recombinant Human TSLP Protein, His-tagged, R127A, R130S | +Inquiry |
◆ Lysates | ||
TSLP-1742MCL | Recombinant Mouse TSLP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, WDR5 has been associated with neurodevelopmental disorders, suggesting a role in non-cancerous diseases as well.
WDR5 regulates the expression of genes critical for neural development, and dysregulation can lead to developmental disorders.
Yes, there are ongoing clinical trials to test the safety and efficacy of WDR5-targeted therapies in cancer patients.
Some studies suggest a potential link between WDR5 and autoimmune diseases, but further research is needed to confirm this association.
Elevated levels of WDR5 in certain cancers can serve as a diagnostic marker when detected in patient samples.
Customer Reviews (3)
Write a reviewThe TSLP protein offered by the manufacturer excels in its quality and is an excellent match for my experimental requirements.
Their team of experts is readily available to address any queries or concerns I may have regarding the TSLP protein.
Their team of experts is readily available to address any concerns or queries I may have regarding the TSLP protein.
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