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Recombinant Human TSLP

Cat.No. : TSLP-8307H
Product Overview : A DNA sequence encoding Human TSLP was expressed.
  • Specification
  • Gene Information
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Description : Thymic stromal lymphopoietin (TSLP) is an IL-7-like epithelial cell-derived cytokine that supports differentiation and long-term growth of B cells. It is expressed in the heart, liver, testis and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5 but uses kinases other than the JAKs for activation. It activates DCs primed na?ve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFα) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation. TSLP prohibits apoptosis and stimulates growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells.
Species : Human
Form : This recombinant protein was 0.2 μm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Molecular Mass : The predicted molecular weight of Recombinant Human TSLP is Mr 15 kDa.
AA Sequence : myd ftncdfekik aaylstiskd litymsgtks tefnntvscs nrphclteiq sltfnptagc aslakemfam ktkaalaiwc pgysetqina tqamkkrrkr kvttnkcleq vsqlqglwrr fnrpllkqq
Endotoxin : <1.0 eu/μg as determined by the lal>
Purity : >95% by SDS-PAGE and analyzed by silver stain.
Storage : The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name : TSLP thymic stromal lymphopoietin [ Homo sapiens ]
Official Symbol : TSLP
Synonyms : TSLP; thymic stromal lymphopoietin;
Gene ID : 85480
mRNA Refseq : NM_033035
Protein Refseq : NP_149024
MIM : 607003
UniProt ID : Q969D9
Chromosome Location : 5q22.1
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function : cytokine activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can WDR5 play a role in non-cancerous diseases? 05/27/2022

Yes, WDR5 has been associated with neurodevelopmental disorders, suggesting a role in non-cancerous diseases as well.

How does WDR5 affect neurodevelopment? 05/08/2020

WDR5 regulates the expression of genes critical for neural development, and dysregulation can lead to developmental disorders.

Are there any clinical trials involving WDR5-targeted therapies? 01/15/2020

Yes, there are ongoing clinical trials to test the safety and efficacy of WDR5-targeted therapies in cancer patients.

Is there a connection between WDR5 and autoimmune diseases? 02/01/2018

Some studies suggest a potential link between WDR5 and autoimmune diseases, but further research is needed to confirm this association.

How can WDR5 be used as a diagnostic marker for cancer? 11/16/2016

Elevated levels of WDR5 in certain cancers can serve as a diagnostic marker when detected in patient samples.

Customer Reviews (3)

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04/04/2019

    The TSLP protein offered by the manufacturer excels in its quality and is an excellent match for my experimental requirements.

    02/25/2019

      Their team of experts is readily available to address any queries or concerns I may have regarding the TSLP protein.

      11/22/2016

        Their team of experts is readily available to address any concerns or queries I may have regarding the TSLP protein.

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