Native Human TIMP2

• Cat.No.: TIMP2-8460H
• Product Overview: LPA was purified from Human Fibroblasts.

Specification

• Description: Glycoprotein that belongs to a family which takes part in the activation and regulation of the MMP-activity. Forms a non-covalent stoichiometric complex with latent and active MMP"s. Inhibits the activities of MMP-1, MMP-2, MMP-12 and transin
• Source: Human Fibroblasts
• Species: Human
• Form: In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl2; 1 μM ZnCl2; 0.05% Brij 35; 0,05% NaN3
• Molecular Mass: ~21kDa (non-reduced); ~24kDa (reduced) (SDS-PAGE).
• Purity: ≥0% by SDS - PAGE
• Storage: Stable if stored at -80°C. Repeated freezing and thawing should be avoided.
• Concentration: ~100 μg/ml
• Shipping: Dry Ice

Gene Information

• Gene Name: TIMP2 TIMP metallopeptidase inhibitor 2 [ Homo sapiens ]
• Official Symbol: TIMP2
• Synonyms: TIMP2; TIMP metallopeptidase inhibitor 2; tissue inhibitor of metalloproteinase 2; metalloproteinase inhibitor 2; CSC 21K; TIMP-2; tissue inhibitor of metalloproteinases 2; CSC-21K
• Gene ID: 7077
• mRNA Refseq: NM_003255
• Protein Refseq: NP_003246
• MIM: 188825
• UniProt ID: P16035
• Chromosome Location: 17q25
• Pathway: Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem
• Function: enzyme activator activity; enzyme inhibitor activity; integrin binding; metal ion binding; metalloendopeptidase inhibitor activity