"TNFSF12" Related Products

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Recombinant Human TNFSF12

Cat.No.: TNFSF12-8461H
Product Overview: The recombinant human TWEAK is a 17.0 kDa protein, comprising the TNF-like extraCellular domain of TWEAK and was expressed in E. coli
Description: Human TWEAK is a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. TWEAK, like many other members of the TNF family, is able to induce interleukin-8 synthesis in a number of cell lines.
Source: E. coli
Species: Human
Form: Sterile filtered and lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 0.1 M L-Arg.
Bio-activity: The ED?? as determined by the dose-dependent stimulation of IL-8 production by human PBMC is less than 10 ng/ml.
Molecular Mass: 17.0 kDa
Endotoxin: <0.1>
Purity: ≥98% by SDS - PAGE; ≥98% by HPLC
Storage: The lyophilized human TWEAK is best-stored desiccated below 0℃. Reconstituted TWEAK should be stored in working aliquots at -20℃.
Reconstitution: Reconstitute in 10 mM Sodium Phosphate (pH 7.5) to a concentration of 1 mg/ml. This solution can then be diluted into other aqueous buffers
Shipping: Blue ice
Gene Name: TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 [ Homo sapiens ]
Official Symbol: TNFSF12?
Synonyms: TNFSF12; tumor necrosis factor (ligand) superfamily, member 12; tumor necrosis factor ligand superfamily member 12; APO3L; DR3LG; TWEAK; APO3 ligand; APO3/DR3 ligand; TNF-related WEAK inducer of apoptosis; MGC20669; MGC129581;
Gene ID: 8742
mRNA Refseq: NM_003809
Protein Refseq: NP_003800
MIM: 602695
UniProt ID: O43508
Chromosome Location: 17p13.1
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Gene Expression, organism-specific biosystem; Regulation of mRNA Stability by Proteins that Bind AU-rich Elements, organism-specific biosystem; Stabilization of mRNA by HuR, organism-specific biosystem;
Function: cytokine activity; cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding;

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