"ATF2" Related Products

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Recombinant Huamn ATF2, His-tagged

Cat.No.: ATF2-8502H
Product Overview: Recombinant Huamn ATF2, fused with His tag, was expressed in E. coli.
Description: The activating transcription factor 2 (ATF2), also known as CRE-BP1 (cAMP-responsive element binding protein 1), is a member of the leucine zipper family of DNA binding proteins and binds to both AP-1 and CRE DNA response elements of many viral and cellular promoters. ATF2 can be activated by a diverse number of cellular stresses such as inflammatory cytokines, genotoxic agents and UV irradiation through MAPK pathway. It is activated through phosphorylation at two phosphosites of Thr69 and Thr71 by upstream activators like JNK/p38 (MAPK14, SAPK2A).
Source: E. coli
Species: Human
Tag: His
Form: 20 mM Tris-Cl, pH 7.9, 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
AA Sequence: MKFKLHVNSA RQYKDLWNMS DDKPFLCTAP GCGQRFTNED HLAVHKHKHE MTLKFGPARN DSVIVADQTP TPTRFLKNCE EVGLFNELAS PFENEFKKAS EDDIKKMPLD LSPLATPIIR SKIEEPSVVE TTHQDSPLPH PESTTSDEKE VPLAQTAQPT SAIVRPASLQ VPNVLLTSSD SSVIIQQAVP SPTSSTVITQ APSSNRPIVP VPGPFPLLLH LPNGQTMPVA IPASITSSNV HVPAAVPLVR PVTMVPSVPG IPGPSSPQPV QSEAKMRLKA ALTQQHPPVT NGDTVKGHGS GLVRTQSEES RPQSLQQPAT STTETPASPA HTTPQTQSTS GRRRRAANED PDEKRRKFLE RNRAAASRCR QKRKVWVQSL EKKAEDLSSL NGQLQSEVTL LRNEVAQLKQ LLLAHKDCPV TAMQKKSGYH TADKDDSSED ISVPSSPHTE AIQHSSVSTS NGVSSTSKAE AVATSVLTQM ADQSTEPALS QIVMAPSSQS QPSGS
Purity: >95% as determined by SDS-PAGE
Storage: -80 °C
Shipping: Dry Ice
Gene Name: ATF2 activating transcription factor 2 [ Homo sapiens ]
Official Symbol: ATF2
Synonyms: ATF2; activating transcription factor 2; HB16; CREB2; TREB7; CRE-BP1; cyclic AMP-dependent transcription factor ATF-2; CREB-2; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; cAMP response element-binding protein CRE-BP1; cyclic AMP-responsive element-binding protein 2; cAMP responsive element binding protein 2, formerly; activating transcription factor 2 splice variant ATF2-var2
Gene ID: 1386
mRNA Refseq: NM_001256090
Protein Refseq: NP_001243019
MIM: 123811
UniProt ID: Q3B7B7
Chromosome Location: 2q32
Pathway: AGE/RAGE pathway, organism-specific biosystem; ATF-2 transcription factor network, organism-specific biosystem; Alcoholism, organism-specific biosystem

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