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Recombinant Human POLR2H, GST-tagged

Cat.No. : POLR2H-8509H
Product Overview : Recombinant Human POLR2H,fused with GST tag,was expressed in E. coli.
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Description : The RPB8 subunit is present in all three types of eukaryotic RNA polymerases and is highly conserved during evolution. It is an essential subunit required for the transcription of nuclear genes. Rpb8 interacts with the largest subunit Rpb1, and with Rpb3 and Rpb11, two smaller subunits. hRPB8 interacts with single-stranded DNA nonspecifically. When DNA is damaged in cells, the breast and ovarian tumor suppressor BRCA1 ubiquitinates RPB8, which may relate with the BRCA1-dependent cell survival.
Source : E. coli
Species : Human
Tag : GST
Form : 20 mM Tris-Cl, pH 7.9, 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
AA Sequence : MAGILFEDIF DVKDIDPEGK KFDRVSRLHC ESESFKMDLI LDVNIQIYPV DLGDKFRLVI ASTLYEDGTL DDGEYNPTDD RPSRADQFEY VMYGKVYRIE GDETSTEAAT RLSAYVSYGG LLMRLQGDAN NLHGFEVDSR VYLLMKKLAF
Purity : >95% as determined by SDS-PAGE
Storage : -80 °C
Concentration : 300 μg/ml
Shipping : Dry Ice
Gene Name : POLR2H polymerase (RNA) II (DNA directed) polypeptide H [ Homo sapiens ]
Official Symbol : POLR2H
Synonyms : POLR2H; polymerase (RNA) II (DNA directed) polypeptide H; DNA-directed RNA polymerases I, II, and III subunit RPABC3; RPB8; hRPB8; RPB8 homolog; DNA-directed RNA polymerase II subunit H; RNA polymerases I, II, and III subunit ABC3; DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide; RPB17; RPABC3; hsRPB8;
Gene ID : 5437
mRNA Refseq : NM_006232
Protein Refseq : NP_006223
MIM : 606023
UniProt ID : P52434
Chromosome Location : 3q28
Pathway : Abortive elongation of HIV-1 transcript in the absence of Tat, organism-specific biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; DNA Repair, organism-specific biosystem; Disease, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem; Eukaryotic Transcription Initiation, organism-specific biosystem;
Function : DNA-directed RNA polymerase activity; contributes_to protein kinase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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