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Recombinant Human Bone Morphogenetic Protein 6

Cat.No. : BMP6-42H
Product Overview : Recombinant Human BMP6 was expressed in E. coli.
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  • Gene Information
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Cat. No. : BMP6-42H
Description : The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
Source : E. coli
Molecular Mass : monomer (15 kDa), dimer (30 kDa)
Purity : ≥98% as determined by SDS­PAGE and HPLC.
Physical Form : Sterile filtered and lyophilized with no additives
Appearance : Lyophilized protein
Endotoxin Level : <0.1 ng/μg
Biological Activity : Recombinant human BMP-6 is biologically active. The ED50 as determined by dose-dependent induction of alkaline phosphatase activity with C2C12 cells is in the range of 2-12 µg/ml.
Reconstitution : Reconstitute to a concentration of 0.1-1.0 mg/ml in sterile 20 mM acetic acid. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Storage : -20°C
OfficialSymbol : BMP6
Gene Name : BMP6 bone morphogenetic protein 6 [ Homo sapiens ]
Synonyms : BMP6; bone morphogenetic protein 6; VGR; VGR1; vegetal related growth factor (TGFB- related); Bone morphogenetic protein 6; VG-1-related protein; VG-1-R; VGR-1; BMP-6; Vg1-related sequence; vegetal-related (TGFB related) cytokine
Gene ID : 654
mRNA Refseq : NM_001718
Protein Refseq : NP_001709
MIM : 112266
UniProt ID : P22004
Chromosome Location : 6p24-p23
Pathway : BMP receptor signaling; Endochondral Ossification; Id Signaling Pathway; TGF-beta signaling pathway
Function : cytokine activity; growth factor activity; BMP receptor binding; protein heterodimerization activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any ongoing clinical trials involving BMP6? 01/27/2022

Yes, there are several ongoing clinical trials investigating the therapeutic applications of BMP6, including its use in bone regeneration and the treatment of musculoskeletal disorders.

Can BMP6 be used in conjunction with other growth factors? 10/09/2017

Yes, BMP6 is often used in combination with other growth factors and scaffolds to enhance its regenerative potential, especially in tissue engineering applications.

Is BMP6 only relevant for bone-related conditions? 11/01/2016

No, BMP6's influence extends beyond bone health. It has been implicated in various cellular processes, including iron homeostasis, and its therapeutic potential is being explored in multiple medical fields.

How does BMP6 contribute to the treatment of bone disorders? 08/08/2016

BMP6 has therapeutic potential in treating bone disorders, such as non-union fractures and osteoporosis. Its ability to stimulate bone formation makes it a valuable candidate for regenerative medicine.

Can BMP6 be administered systemically or is it site-specific? 01/15/2016

BMP6 can be administered both locally and systemically, depending on the therapeutic goals. Local administration is often preferred for targeted effects, such as bone regeneration at a specific site.

Customer Reviews (3)

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Reviews
08/14/2022

    The BMP6 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.

    11/02/2020

      The BMP6 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.

      10/15/2019

        This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.

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