Native Human CPB2


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Native Human CPB2

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Cat.No. : CPB2-8517H
Product Overview : Native Human TAFI is prepared from fresh frozen human plasma by a modification of the method of Bajzar, et. al.
Description : Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region.
Source : Human
Species : Human
Form : 20 mM Hepes, 150 mM NaCl, pH 7.4
Bio-activity : Hippuryl-L-Arginine hydrolysis. Activity is determined measuring the rate of hydrolysis of hipuryl-L- Arg following activation with the thrombin/ thrombomodulin complex.
Molecular Mass : 60,000
Purity : >95% by SDS-PAGE
Storage : -80℃
Gene Name : CPB2 carboxypeptidase B2 (plasma) [ Homo sapiens ]
Official Symbol : CPB2
Synonyms : CPB2; carboxypeptidase B2 (plasma); carboxypeptidase B2 (plasma, carboxypeptidase U); carboxypeptidase B2; carboxypeptidase R; carboxypeptidase U; CPU; PCPB; plasma carboxypeptidase B; TAFI; thrombin activatable fibrinolysis inhibitor; carboxypeptidase B-like protein; thrombin-activable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor;
Gene ID : 1361
mRNA Refseq : NM_001872
Protein Refseq : NP_001863
MIM : 603101
UniProt ID : Q96IY4
Chromosome Location : 13q14.11
Pathway : Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Pancreatic secretion, organism-specific biosystem; Pancreatic secretion, conserved biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and absorption, conserved biosystem;
Function : metal ion binding; metallocarboxypeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding;

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