Native Human ACHE


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Native Human ACHE

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Cat.No. : ACHE-8345H
Product Overview : Native Human ACHE was purified from Human erythrocytes.
Description : Acetylcholinesterase (AChE) is involved in cholinergic transmission, where it catalyses the hydrolysis of the neurotransmitter acetylcholine. A membrane-bound protein on the post-synaptic membrane. Also found in some non-neuronal cells, such as erythrocytes where its function is unclear. The erythrocyte enzyme extracted from the membrane anchor, using Triton-X 100, has a molecular weight 160,000. AChE is the target the organophosphorus insecticides such as parathion and malathion, all of which irreversibly inhibit the enzyme. Depressed levels of AChE activity is a sensitive indicator of exposure to these agents. It is also the target of anti-Alzheimer""s drrugs such as tacrine, which are reversible inhibitors of the enzyme. Raised levels of AChE in amniotic fluid are indicative of foetal neural tube defects.
Source : Human erythrocytes
Species : Human
Unit Definition : One unit will hydrolyse one micromole of Acetylthiocholine Iodide per minute at 37°C and pH 7.4.
Concentration : >450 U/mg
Gene Name : ACHE acetylcholinesterase [ Homo sapiens ]
Official Symbol : ACHE
Synonyms : ACHE; acetylcholinesterase; acetylcholinesterase (YT blood group) , acetylcholinesterase (Yt blood group) , YT; Yt blood group; apoptosis-related acetylcholinesterase; YT; ACEE; ARACHE; N-ACHE;
Gene ID : 43
mRNA Refseq : NM_000665
Protein Refseq : NP_000656
MIM : 100740
UniProt ID : P22303
Chromosome Location : 7q22
Pathway : ATF-2 transcription factor network, organism-specific biosystem; Acetylcholine Synthesis, organism-specific biosystem; Biogenic Amine Synthesis, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Glycerophospholipid metabolism, organism-specific biosystem; Glycerophospholipid metabolism, conserved biosystem; Monoamine Transport, organism-specific biosystem;
Function : acetylcholine binding; acetylcholine binding; acetylcholinesterase activity; acetylcholinesterase activity; beta-amyloid binding; carboxylesterase activity; cholinesterase activity; collagen binding; hydrolase activity; laminin binding; protein binding; protein homodimerization activity; protein homodimerization activity; protein self-association; serine hydrolase activity;

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