"PDGFC" Related Products


Recombinant Human PDGFC, His-tagged

Cat. No.: PDGFC-208H
Product Overview: Recombinant Human PDGFC (Val235-Gly345) fused with 6­His tag, was expressed in E. coli.
Description: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.
Source: E. coli
Molecular Mass: The protein(monomer) has a calculated molecular mass of 13.4 kDa
Predicted N terminal: Met
Formulation: Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.
Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Activity: Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. The ED50 for this effect is typically 70 - 350 ng/mL.
EndotoxinLevel: < 0.10 EU per 1 μg of the protein by the LAL method.
Reconstitution: Reconstitute at 100 µg/mL in sterile 4 mM HCl.
Storage: 12 months from date of receipt, ­20 to ­70 °C as supplied. Avoid repeated freeze­thaw cycles.
OfficialSymbol: PDGFC
Gene Name: PDGFC platelet derived growth factor C [ Homo sapiens ]
Synonyms: platelet derived growth factor C; SCDGF; FALLOTEIN; PDGFC; spinal cord-derived growth factor; secretory growth factor-like protein; fallotein; fallotein; PDGF-C; VEGF-E; Spinal cord-derived growth factor; platelet-derived growth factor C
Gene ID: 56034
mRNA Refseq: NM_016205
Protein Refseq: NP_057289
MIM: 608452
UniProt ID: Q9NRA1
Chromosome Location: 4q32
Pathway: Cytokine-cytokine receptor interaction; Regulation of actin cytoskeleton; Focal adhesion; Gap junction; Melanoma; Prostate cancer; Signaling by PDGF; Signaling by VEGF
Function: platelet-derived growth factor receptor binding; protein homodimerization activity; growth factor activity; cell surface binding

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