"BACE1" Related Products

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Recombinant Human BACE1, GST-tagged

Cat. No.: BACE1-102H
Product Overview: Recombinant Human BACE1 (22 a.a. - 501 a.a.) fused with GST-tag at N-terminal, was expressed in vitro wheat germ expression system.
Description: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer''s disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.
Source: wheat germ
Molecular Mass: 78.54 kDa
Sequence: TQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
Purification: Glutathione Sepharose 4 Fast Flow
Storage buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.
Applications: ELISA; WB
Storage: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note: Best use within three months from the date of receipt of this protein.
OfficialSymbol: BACE1
Gene Name: BACE1 beta-site APP-cleaving enzyme 1 [ Homo sapiens ]
Synonyms: BACE1; beta-site APP-cleaving enzyme 1; ASP2; BACE; HSPC104; FLJ90568; KIAA1149; beta-site APP-cleaving enzyme; Beta-secretase 1; EC 3.4.23.46; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Membrane-associated aspartic protease 2; Memapsin-2; Aspartyl protease 2; transmembrane aspartic proteinase Asp2; APP beta-secretase; Asp 2
Gene ID: 23621
mRNA Refseq: NM_012104
Protein Refseq: NP_036236
MIM: 604252
UniProt ID: P56817
Chromosome Location: 11q23.2-q23.3
Pathway: Alzheimer"s disease; Alzheimers Disease
Function: aspartic-type endopeptidase activity; beta-aspartyl-peptidase activity; enzyme binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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