Recombinant Human HES2, His-tagged

• Cat.No.: HES2-15904H
• Product Overview: Recombinant human HES2 protein, fused to His tag at N-terminus, was expressed in E.coli.

Specification

• Description: Hairy and enhancer of split 2, also known as HES2, is a member of the HES family and contains one basic helix-loop-helix (bHLH) domain and one orange domain. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. Activation of Notch signaling pathway leads to activation of HES family genes through the interaction between Notch intracellular domain and RBPSUH (CSL). HES2 is expressed in a variety of adult and embryonic tissue.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
• Molecular Mass: 20.9 kDa (196aa)
• Protein length: 1-173aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMGLPRRA GDAAELRKSL KPLLEKRRRA RINQSLSQLK GLILPLLGRE NSNCSKLEKA DVLEMTVRFL QELPASSWPT AAPLPCDSYR EGYSACVARL ARVLPACRVL EPAVSARLLE HLWRRAASAT LDGGRAGDSS GPSAPAPAPA SAPEPASAPV PSPPSPPCGP GLWRPW
• Purity: >80% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term. For long term storage, aliquot and store at at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: HES2 hairy and enhancer of split 2 (Drosophila) [ Homo sapiens ]
• Official Symbol: HES2
• Synonyms: HES2; hairy and enhancer of split 2 (Drosophila); transcription factor HES-2; bHLHb40; class B basic helix-loop-helix protein 40
• Gene ID: 54626
• mRNA Refseq: NM_019089
• Protein Refseq: NP_061962
• MIM: 609970
• UniProt ID: Q9Y543
• Chromosome Location: 1p36.31
• Function: DNA binding; double-stranded DNA binding; transcription factor binding