Recombinant Human SH3BP2, His-tagged


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Recombinant Human SH3BP2, His-tagged

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Cat.No. : SH3BP2-9178H
Product Overview : Recombinant human SH3BP2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description : The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : E.coli
Species : Human
Tag : His
Protein length : 1-301a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : SH3BP2 SH3-domain binding protein 2 [ Homo sapiens ]
Official Symbol : SH3BP2
Synonyms : SH3BP2; SH3-domain binding protein 2; Cherubism; SH3 domain-binding protein 2; CRBM; RES4 23; Abl-SH3 binding protein 2; TNFAIP3 interacting protein 2; 3BP2; CRPM; 3BP-2; RES4-23; FLJ42079; FLJ54978;
Gene ID : 6452
mRNA Refseq : NM_001122681
Protein Refseq : NP_001116153
MIM : 602104
UniProt ID : P78314
Chromosome Location : 4p16.3
Pathway : B Cell Receptor Signaling Pathway, organism-specific biosystem; Natural killer cell mediated cytotoxicity, organism-specific biosystem; Natural killer cell mediated cytotoxicity, conserved biosystem; T Cell Receptor Signaling Pathway, organism-specific biosystem; TCR signaling in naive CD4+ T cells, organism-specific biosystem;
Function : SH3 domain binding; SH3/SH2 adaptor activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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