Recombinant Human ABI1, GST-tagged ABI1-9246H

Recombinant Human ABI1, GST-tagged

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Recombinant Human ABI1, GST-tagged

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Cat.No. : ABI1-9246H
Product Overview : Recombinant Human ABI1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description : This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.
Source : E.coli
Species : Human
Tag : GST
Protein length : N-term-304a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : ABI1 abl-interactor 1 [ Homo sapiens ]
Official Symbol : ABI1
Synonyms : ABI1; abl-interactor 1; spectrin SH3 domain binding protein 1 , SSH3BP1; abl interactor 1; ABI 1; E3B1; Abelson interactor 1; nap1 binding protein; abl-binding protein 4; interactor protein AblBP4; Abl-interactor protein 1 long; eps8 SH3 domain-binding protein; spectrin SH3 domain-binding protein 1; ABI-1; ABLBP4; NAP1BP; SSH3BP; SSH3BP1;
Gene ID : 10006
mRNA Refseq : NM_001012750
Protein Refseq : NP_001012768
MIM : 603050
UniProt ID : Q8IZP0
Chromosome Location : 10p12.1
Pathway : E-cadherin signaling in the nascent adherens junction, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; ErbB1 downstream signaling, organism-specific biosystem; RAC1 signaling pathway, organism-specific biosystem; Regulation of RAC1 activity, organism-specific biosystem; Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem; T Cell Receptor Signaling Pathway, organism-specific biosystem;
Function : cytoskeletal protein binding; protein binding; protein tyrosine kinase activator activity;

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