Recombinant Human ACTL7A, His-tagged

• Cat.No.: ACTL7A-9336H
• Product Overview: Recombinant Human ACTL7A protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-280a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: ACTL7A actin-like 7A [ Homo sapiens ]
• Official Symbol: ACTL7A
• Synonyms: ACTL7A; actin-like 7A; actin-like protein 7A; actin-like 7-alpha; actin-like-7-alpha
• Gene ID: 10881
• mRNA Refseq: NM_006687
• Protein Refseq: NP_006678
• MIM: 604303
• UniProt ID: Q9Y615
• Chromosome Location: 9q31
• Function: structural constituent of cytoskeleton