Recombinant Human ACTN3, GST-tagged

• Cat.No.: ACTN3-9341H
• Product Overview: Recombinant Human ACTN3 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants. The reference genome contains the non-coding allele. The non-functional allele of this gene is associated with elite athlete status.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 577-624a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ACTN3 actinin, alpha 3 [ Homo sapiens ]
• Official Symbol: ACTN3
• Synonyms: ACTN3; actinin, alpha 3; alpha-actinin-3; F-actin cross-linking protein; alpha-actinin skeletal muscle; MGC117002; MGC117005
• Gene ID: 89
• mRNA Refseq: NM_001104
• Protein Refseq: NP_001095
• UniProt ID: Q08043
• Chromosome Location: 11q13-q14
• Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cell-Cell communication, organism-specific biosystem
• Function: actin binding; calcium ion binding; integrin binding; protein binding; protein homodimerization activity; structural constituent of muscle