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Recombinant Human ACVR1C, GST-tagged

Cat.No.: ACVR1C-9356H
Product Overview: Recombinant Human ACVR1C protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.
Source: E.coli
Species: Human
Tag: GST
Protein length: C-term-355a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: ACVR1C activin A receptor, type IC [ Homo sapiens ]
Official Symbol: ACVR1C
Synonyms: ACVR1C; activin A receptor, type IC; activin receptor type-1C; ACVRLK7; ALK7; ALK-7; ACTR-IC; activin receptor type IC; activin receptor-like kinase 7;
Gene ID: 130399
mRNA Refseq: NM_001111031
Protein Refseq: NP_001104501
MIM: 608981
UniProt ID: Q8NER5
Chromosome Location: 2q24.2
Pathway: Developmental Biology, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; Regulation of Signaling by NODAL, organism-specific biosystem; Signaling by NODAL, organism-specific biosystem; TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem;
Function: ATP binding; activin receptor activity, type I; metal ion binding; nucleotide binding; receptor activity; transforming growth factor beta-activated receptor activity;

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