Recombinant Human ADSL, GST-tagged

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Recombinant Human ADSL, GST-tagged

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Cat.No. : ADSL-9449H
Product Overview : Recombinant Human ADSL protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description : Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-354a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : ADSL adenylosuccinate lyase [ Homo sapiens ]
Official Symbol : ADSL
Synonyms : ADSL; adenylosuccinate lyase; adenylosuccinase; ASL; AMPS; ASASE;
Gene ID : 158
mRNA Refseq : NM_000026
Protein Refseq : NP_000017
MIM : 608222
UniProt ID : P30566
Chromosome Location : 22q13.1
Pathway : Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Inosine monophosphate biosynthesis, PRPP + glutamine => IMP, organism-specific biosystem; Inosine monophosphate biosynthesis, PRPP + glutamine => IMP, conserved biosystem; Metabolic pathways, organism-specific biosystem;
Function : (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; NOT N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; N6-(1,2-

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