Recombinant Human AKTIP, His-tagged

• Cat.No.: AKTIP-9543H
• Product Overview: Recombinant Human AKTIP protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKBs regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-292a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: AKTIP AKT interacting protein [ Homo sapiens ]
• Official Symbol: AKTIP
• Synonyms: AKTIP; AKT interacting protein; FTS, fused toes (mouse) homolog , fused toes homolog (mouse); AKT-interacting protein; FLJ13258; fused toes homolog; fused toes protein homolog; FT1; FTS
• Gene ID: 64400
• mRNA Refseq: NM_001012398
• Protein Refseq: NP_001012398
• MIM: 608483
• UniProt ID: Q9H8T0
• Chromosome Location: 16q12.2
• Function: protein binding; NOT small conjugating protein ligase activity