Recombinant Human ALDH5A1, His-tagged

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Recombinant Human ALDH5A1, His-tagged

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Cat.No. : ALDH5A1-9562H
Product Overview : Recombinant Human ALDH5A1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description : This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene.
Source : E.coli
Species : Human
Tag : His
Protein length : 175-535a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : ALDH5A1 aldehyde dehydrogenase 5 family, member A1 [ Homo sapiens ]
Official Symbol : ALDH5A1
Synonyms : ALDH5A1; aldehyde dehydrogenase 5 family, member A1; succinate-semialdehyde dehydrogenase, mitochondrial; SSADH; SSDH; succinate semialdehyde dehydrogenase; aldehyde dehydrogenase family 5 member A1; mitochondrial succinate semialdehyde dehydrogenase; NAD(+)-dependent succinic semialdehyde dehydrogenase;
Gene ID : 7915
mRNA Refseq : NM_001080
Protein Refseq : NP_001071
MIM : 610045
UniProt ID : P51649
Chromosome Location : 6p22
Pathway : 4-aminobutyrate degradation I, organism-specific biosystem; 4-aminobutyrate degradation I, conserved biosystem; Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Butanoate metabolism, organism-specific biosystem; Butanoate metabolism, conserved biosystem; Degradation of GABA, organism-specific biosystem;
Function : oxidoreductase activity; protein homodimerization activity; succinate-semialdehyde dehydrogenase activity; succinate-semialdehyde dehydrogenase activity;

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