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Recombinant Human APBA2, GST-tagged

Cat.No. : APBA2-9728H
Product Overview : Recombinant Human APBA2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimers disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimers disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-66a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 [ Homo sapiens ]
Official Symbol : APBA2
Synonyms : APBA2; amyloid beta (A4) precursor protein-binding, family A, member 2; amyloid beta (A4) precursor protein binding, family A, member 2 (X11 like) , MINT2, X11 like , X11L; amyloid beta A4 precursor protein-binding family A member 2; D15S1518E; HsT16821; LIN 10; MGC:14091; mint-2; X11-like protein; adapter protein X11beta; neuron-specific X11L protein; neuronal munc18-1-interacting protein 2; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); X11L; MINT2; LIN-10; X11-BETA; MGC99508;
Gene ID : 321
mRNA Refseq : NM_001130414
Protein Refseq : NP_001123886
MIM : 602712
UniProt ID : Q99767
Chromosome Location : 15q11-q12
Function : protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (17)

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In what diseases may recombinant APBA2 have potential medical applications? 11/12/2022

Current studies have found that the APBA2 may have a promising application in neurosystem-related diseases such as Alzheimer's disease, Parkinson's disease, and epilepsy.

What are the applications of APBA2 in drug screening? 10/26/2022

Recombinant APBA2 protein can be used in drug screening to evaluate the activity and effectiveness of various drug candidates by detecting the binding ability and affinity of different compounds to it.

What is the research significance of APBA2 ? 09/26/2022

As a protein regulating neuronal signaling, APBA2 has potential application prospects in the prevention and treatment of nervous system-related diseases, and is also of great significance for the study of the development, function and pathological mechanism of the nervous system.

How to evaluate the efficacy and safety of APBA2 ? 09/03/2022

The efficacy and safety of APBA2 can be evaluated through in vitro and in vivo pharmacological experiments, toxicity tests, clinical studies and other methods.

What is the relationship between APBA2 and synaptic plasticity? 08/15/2022

The APBA2 can promote the connection between neurons and the formation and stability of synapses, and increase the plasticity of synapses.

What is the antigenicity of APBA2 ? 03/14/2022

At present, no relevant studies have reported the specific antigenicity of APBA2 .

What is the application prospect of APBA2 in neuroethology? 10/13/2021

Recombinant APBA2 protein can be used as an indicator in neurobehavioral experiments to evaluate learning and memory ability in mice and rats.

How to realize the protective effect of APBA2 on neurons? 07/06/2021

The APBA2 can promote the formation and stability of neuronal synapses and strengthen the connections between neurons, thereby protecting neurons from damage.

How to prepare APBA2 efficiently? 03/30/2021

APBA2 protein can be expressed in cells by molecular cloning technology, and the can be purified.

What are the application prospects of recombinant APBA2 in Alzheimer's disease? 03/14/2021

APBA2 plays an important role in regulating neuronal signaling and synaptic function, so it has potential application prospects in neurosystem-related diseases such as Alzheimer's disease.

How can APBA2 be further optimized and improved? 12/30/2020

The performance of APBA2 protein in clinical and scientific applications can be further optimized and improved by changing its structure, enzymolysis site and affinity.

What is the molecular mechanism of APBA2 ? 11/27/2020

APBA2 is a key protein regulating nerve cell signal transmission, which can bind to neurotransmitter receptors, promote neurotransmitter signal transmission, increase synaptic plasticity and promote neuronal differentiation and maturation.

What is the structure of APBA2 ? 08/21/2020

The APBA2 is a protein containing multiple domains, and the three-dimensional structure of some of its structures has been analyzed, including the domain where it binds to the transmitter receptor.

In which experiments is APBA2 widely used? 05/20/2020

Recombinant APBA2 protein has been widely used in experiments of nervous system development, neurodegenerative diseases, synaptic plasticity, drug screening and so on.

How to quantify the binding capacity of APBA2 ? 01/13/2020

Binding quantitative detection of APBA2 can be performed based on in vitro hybridization, molecular crosslinking, biosensor and other technologies.

How does APBA2 bind to neurotransmitter receptors? 07/25/2019

The recombinant APBA2 protein can bind to the intrinsic domain of neurotransmitter receptors, regulating neurotransmitter signaling and synaptic plasticity.

Can APBA2 be obtained through bioengineering? 06/26/2019

Recombinant APBA2 protein can be obtained by molecular cloning technology and cell engineering technology.

Customer Reviews (4)

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12/13/2022

    APBA2 is really amazing, and the results are very consistent every time, you can see that the production process is very careful.

    07/07/2021

      APBA2 they produced has good solubility and can dissolve easily.

      12/14/2020

        After using this recombinant protein, the quantitative accuracy of Western blot was significantly improved.

        11/18/2019

          The catalytic activity of APBA2 is excellent, and it can make tedious chemical reactions simple, and its simplification is to be appreciated.

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