"ARHGAP26" Related Products


Recombinant Human ARHGAP2, His-tagged

Cat.No.: ARHGAP26-9822H
Product Overview: Recombinant Human ARHGAP2His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene.
Source: E.coli
Species: Human
Tag: His
Protein length: 403--759a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: ARHGAP26 Rho GTPase activating protein 26 [ Homo sapiens ]
Official Symbol: ARHGAP26
Synonyms: ARHGAP26; Rho GTPase activating protein 26; rho GTPase-activating protein 26; GRAF; GTPase regulator associated with the focal adhesion kinase pp125; KIAA0621; OPHN1L; OPHN1L1; oligophrenin-1-like protein; GTPase regulator associated with focal adhesion kinase pp125(FAK); GRAF1; FLJ42530;
Gene ID: 23092
mRNA Refseq: NM_001135608
Protein Refseq: NP_001129080
MIM: 605370
UniProt ID: Q9UNA1
Chromosome Location: 5q31
Pathway: Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by Rho GTPases, organism-specific biosystem; Signaling events mediated by focal adhesion kinase, organism-specific biosystem;
Function: GTPase activator activity; Rho GTPase activator activity; SH3 domain binding; cytoskeletal adaptor activity; protein binding;

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