Recombinant Human ARHGAP2, His-tagged

• Cat.No.: ARHGAP26-9822H
• Product Overview: Recombinant Human ARHGAP2His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 403--759a.a.
• Description: Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: ARHGAP26 Rho GTPase activating protein 26 [ Homo sapiens ]
• Official Symbol: ARHGAP26
• Synonyms: ARHGAP26; Rho GTPase activating protein 26; rho GTPase-activating protein 26; GRAF; GTPase regulator associated with the focal adhesion kinase pp125; KIAA0621; OPHN1L; OPHN1L1; oligophrenin-1-like protein; GTPase regulator associated with focal adhesion kinase pp125(FAK); GRAF1; FLJ42530
• Gene ID: 23092
• mRNA Refseq: NM_001135608
• Protein Refseq: NP_001129080
• MIM: 605370
• UniProt ID: Q9UNA1
• Chromosome Location: 5q31
• Pathway: Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by Rho GTPases, organism-specific biosystem; Signaling events mediated by focal adhesion kinase, organism-specific biosystem
• Function: GTPase activator activity; Rho GTPase activator activity; SH3 domain binding; cytoskeletal adaptor activity; protein binding