Recombinant Human ARHGDIB, GST-tagged ARHGDIB-9829H

Recombinant Human ARHGDIB, GST-tagged

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Recombinant Human ARHGDIB, GST-tagged

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Cat.No. : ARHGDIB-9829H
Product Overview : Recombinant Human ARHGDIB protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description : Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-201a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : ARHGDIB Rho GDP dissociation inhibitor (GDI) beta [ Homo sapiens ]
Official Symbol : ARHGDIB
Synonyms : ARHGDIB; Rho GDP dissociation inhibitor (GDI) beta; GDIA2, GDID4, RAP1GN1; rho GDP-dissociation inhibitor 2; Ly GDI; RhoGDI2; Rho GDI 2; rho-GDI beta; D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1;
Gene ID : 397
mRNA Refseq : NM_001175
Protein Refseq : NP_001166
MIM : 602843
UniProt ID : P52566
Chromosome Location : 12p12.3
Pathway : Caspase cascade in apoptosis, organism-specific biosystem; FAS pathway and Stress induction of HSP regulation, organism-specific biosystem; G13 Signaling Pathway, organism-specific biosystem; Neurotrophin signaling pathway, organism-specific biosystem; Neurotrophin signaling pathway, conserved biosystem; Regulation of RhoA activity, organism-specific biosystem; Rho GTPase cycle, organism-specific biosystem;
Function : GTPase activator activity; Rho GDP-dissociation inhibitor activity;

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