Recombinant Human AXIN2, GST-tagged
Cat.No. : | AXIN2-10085H |
Product Overview : | Recombinant Human AXIN2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 30-83a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | AXIN2 axin 2 [ Homo sapiens ] |
Official Symbol : | AXIN2 |
Synonyms : | AXIN2; axin 2; axin-2; axil; conductin; DKFZp781B0869; MGC126582; axin-like protein; axis inhibition protein 2; AXIL; MGC10366; |
Gene ID : | 8313 |
mRNA Refseq : | NM_004655 |
Protein Refseq : | NP_004646 |
MIM : | 604025 |
UniProt ID : | Q9Y2T1 |
Chromosome Location : | 17q23-q24 |
Pathway : | Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Canonical Wnt signaling pathway, organism-specific biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Endometrial cancer, organism-specific biosystem; Endometrial cancer, conserved biosystem; |
Function : | GTPase activator activity; I-SMAD binding; armadillo repeat domain binding; beta-catenin binding; beta-catenin binding; enzyme binding; protein kinase binding; signal transducer activity; ubiquitin protein ligase binding; |
Products Types
◆ Recombinant Protein | ||
AXIN2-566R | Recombinant Rat AXIN2 Protein, His (Fc)-Avi-tagged | +Inquiry |
AXIN2-391H | Recombinant Human AXIN2 Protein, His-tagged | +Inquiry |
AXIN2-917M | Recombinant Mouse AXIN2 Protein, His (Fc)-Avi-tagged | +Inquiry |
AXIN2-9104Z | Recombinant Zebrafish AXIN2 | +Inquiry |
AXIN2-3796H | Recombinant Human AXIN2, His-tagged | +Inquiry |
◆ Lysates | ||
AXIN2-8554HCL | Recombinant Human AXIN2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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