Recombinant Human B2M, GST-tagged
Cat.No. : | B2M-10092H |
Product Overview : | Recombinant Human B2M protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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- Gene Information
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Description : | This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 22-119a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | B2M beta-2-microglobulin [ Homo sapiens ] |
Official Symbol : | B2M |
Synonyms : | B2M; beta-2-microglobulin; beta-2-microglobin; beta chain of MHC class I molecules; |
Gene ID : | 567 |
mRNA Refseq : | NM_004048 |
Protein Refseq : | NP_004039 |
MIM : | 109700 |
UniProt ID : | P61769 |
Chromosome Location : | 15q21-q22.2 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Amyloids, organism-specific biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Class I MHC mediated antigen processing & |
Function : | protein binding; |
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◆ Native Protein | ||
B2M-5366H | Native Human Beta-2-Microglobulin | +Inquiry |
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B2M-13H | Native Human B2M | +Inquiry |
◆ Lysates | ||
B2M-2204HCL | Recombinant Human B2M cell lysate | +Inquiry |
B2M-1512CCL | Recombinant Cynomolgus B2M cell lysate | +Inquiry |
B2M-1656MCL | Recombinant Mouse B2M cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe normal reference range for B2M varies depending on age, gender, weight, individual differences, and other factors. In general, the normal reference range is between 0~3.0mg/L.
Causes of reduced B2M include liver and kidney failure, tuberculosis, HIV infection, rheumatoid arthritis, systemic lupus erythematosus and other diseases.
B2M plays an important role in the diagnosis and prognosis assessment of malignancies such as lymphoma and multiple myeloma. Elevated B2M levels can also indicate worsening or recurrence of certain autoimmune diseases, such as systemic lupus erythematosus.
It has a variety of physiological functions in the immune system, including inducing immune response, participating in lymphocyte proliferation and differentiation, regulating immune tolerance, and participating in tumor immune surveillance.
The levels can be affected by a variety of factors, such as cancer, inflammation, autoimmune diseases, infections, medications, etc.
This is associated with many diseases, including lymphoma, normal stress hydrocephalus, HIV infection, rheumatoid arthritis, nephrotic syndrome, cirrhosis, systemic lupus erythematosus, etc.
Customer Reviews (3)
Write a reviewTo meet the needs of biological activity experiments
High purity, no impurities.
The expression level is high, which can meet the daily experimental needs.
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