"CBLC" Related Products

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Recombinant Human CBLC, His-tagged

Cat.No.: CBLC-10757H
Product Overview: Recombinant Human CBLC protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene.
Source: E.coli
Species: Human
Tag: His
Protein length: N-term-350a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: CBLC Cbl proto-oncogene, E3 ubiquitin protein ligase C [ Homo sapiens ]
Official Symbol: CBLC
Synonyms: CBLC; Cbl proto-oncogene, E3 ubiquitin protein ligase C; Cas Br M (murine) ecotropic retroviral transforming sequence c , Cas Br M (murine) ectropic retroviral transforming sequence c; signal transduction protein CBL-C; CBL 3; CBL SL; RNF57; RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Cas-Br-M (murine) ectropic retroviral transforming sequence c; Cas-Br-M (murine) ecotropic retroviral transforming sequence c; CBL-3; CBL-SL;
Gene ID: 23624
mRNA Refseq: NM_001130852
Protein Refseq: NP_001124324
MIM: 608453
UniProt ID: Q9ULV8
Chromosome Location: 19q13.2
Pathway: Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem;
Function: SH3 domain binding; calcium ion binding; epidermal growth factor receptor binding; phosphotyrosine binding; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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