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Recombinant Human CD1D, His-tagged

Cat.No. : CD1D-10920H
Product Overview : Recombinant Human CD1D protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
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Description : This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).
Source : E.coli
Species : Human
Tag : His
Protein length : 18-302a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : CD1D CD1d molecule [ Homo sapiens ]
Official Symbol : CD1D
Synonyms : CD1D; CD1d molecule; CD1d antigen , CD1D antigen, d polypeptide; antigen-presenting glycoprotein CD1d; R3G1; thymocyte antigen CD1D; CD1D antigen, d polypeptide; T-cell surface glycoprotein CD1d; differentiation antigen CD1-alpha-3; HMC class I antigen-like glycoprotein CD1D; R3; CD1A; MGC34622;
Gene ID : 912
mRNA Refseq : NM_001766
Protein Refseq : NP_001757
MIM : 188410
UniProt ID : P15813
Chromosome Location : 1q22-q23
Pathway : Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem;
Function : beta-2-microglobulin binding; cell adhesion molecule binding; eukaryotic cell surface binding; exogenous lipid antigen binding; histone binding; lipid antigen binding; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Are there any drugs targeting CD1D in development? 12/17/2022

Some pharmaceutical companies are researching and developing drugs that target CD1D for therapeutic purposes, although these are still in the early stages of development.

How is CD1D involved in lipid antigen presentation? 06/21/2022

CD1D binds and presents lipid antigens to NKT cells, facilitating immune responses against pathogens or aberrant cells.

How does CD1D differ from other antigen-presenting proteins like MHC? 02/20/2022

CD1D primarily presents lipid antigens, while major histocompatibility complex (MHC) proteins present peptide antigens. CD1D is crucial for lipid-specific immune responses.

In which diseases is CD1D deficiency implicated? 10/27/2020

CD1D deficiency has been associated with an increased susceptibility to certain infections and a potential link to autoimmune disorders.

Are there any clinical trials targeting CD1D? 02/04/2018

Yes, several clinical trials are exploring the modulation of CD1D in various diseases, including cancer and autoimmune disorders, to assess its therapeutic potential.

Customer Reviews (3)

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03/14/2020

    The CD1D protein's versatility allows it to be effectively employed in various experimental designs, further enhancing its suitability for diverse research needs.

    02/27/2020

      Their extensive knowledge and expertise can help troubleshoot issues or provide guidance on experimental design, enabling you to overcome obstacles and achieve your research goals.

      04/15/2016

        In protein electron microscopy structure analysis, the CD1D protein demonstrates outstanding performance.

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