Recombinant Human COL25A1, His-tagged

• Cat.No.: COL25A1-11430H
• Product Overview: Recombinant Human COL25A1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: C-term-332a.a.
• Description: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: COL25A1 collagen, type XXV, alpha 1 [ Homo sapiens ]
• Official Symbol: COL25A1
• Synonyms: COL25A1; collagen, type XXV, alpha 1; collagen alpha-1(XXV) chain; alzheimer disease amyloid-associated protein; collagenous Alzheimer amyloid plaque component; collagen-like Alzheimer amyloid plaque component; AMY; CLAC; CLACP; CLAC-P
• Gene ID: 84570
• mRNA Refseq: NM_001256074
• Protein Refseq: NP_001243003
• MIM: 610004
• UniProt ID: Q9BXS0
• Chromosome Location: 4q25
• Function: beta-amyloid binding; heparin binding