"COL25A1" Related Products

Recombinant Human COL25A1, His-tagged

Cat.No.: COL25A1-11430H
Product Overview: Recombinant Human COL25A1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene.
Source: E.coli
Species: Human
Tag: His
Protein length: C-term-332a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: COL25A1 collagen, type XXV, alpha 1 [ Homo sapiens ]
Official Symbol: COL25A1
Synonyms: COL25A1; collagen, type XXV, alpha 1; collagen alpha-1(XXV) chain; alzheimer disease amyloid-associated protein; collagenous Alzheimer amyloid plaque component; collagen-like Alzheimer amyloid plaque component; AMY; CLAC; CLACP; CLAC-P;
Gene ID: 84570
mRNA Refseq: NM_001256074
Protein Refseq: NP_001243003
MIM: 610004
UniProt ID: Q9BXS0
Chromosome Location: 4q25
Function: beta-amyloid binding; heparin binding;

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