"COX17" Related Products


Recombinant Human COX17, GST-tagged

Cat.No.: COX17-11488H
Product Overview: Recombinant Human COX17 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.
Source: E.coli
Species: Human
Tag: GST
Protein length: 1-63a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: COX17 COX17 cytochrome c oxidase assembly homolog (S. cerevisiae) [ Homo sapiens ]
Official Symbol: COX17
Synonyms: COX17; COX17 cytochrome c oxidase assembly homolog (S. cerevisiae); COX17 (yeast) homolog, cytochrome c oxidase assembly protein , COX17 homolog, cytochrome c oxidase assembly protein (S. cerevisiae) , COX17 homolog, cytochrome c oxidase assembly protein (yeast); cytochrome c oxidase copper chaperone; human homolog of yeast mitochondrial copper recruitment; MGC104397; MGC117386;
Gene ID: 10063
mRNA Refseq: NM_005694
Protein Refseq: NP_005685
MIM: 604813
UniProt ID: Q14061
Chromosome Location: 3q13.33
Pathway: Cytochrome c oxidase, organism-specific biosystem; Cytochrome c oxidase, conserved biosystem; Electron Transport Chain, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Mitochondrial Protein Import, organism-specific biosystem; Oxidative phosphorylation, organism-specific biosystem;
Function: copper chaperone activity; copper ion binding; enzyme activator activity; metal ion binding;

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