Recombinant Human CPSF3, GST-tagged

• Cat.No.: CPSF3-11537H
• Product Overview: Recombinant Human CPSF3 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: C-term-348a.a.
• Description: This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3-end pre-mRNA processing.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CPSF3 cleavage and polyadenylation specific factor 3, 73kDa [ Homo sapiens ]
• Official Symbol: CPSF3
• Synonyms: CPSF3; cleavage and polyadenylation specific factor 3, 73kDa; cleavage and polyadenylation specific factor 3, 73kD subunit; cleavage and polyadenylation specificity factor subunit 3; CPSF 73; CPSF73; YSH1; CPSF 73 kDa subunit; mRNA 3-end-processing endonuclease CPSF-73; cleavage and polyadenylation specificity factor 3; cleavage and polyadenylation specificity factor 73 kDa subunit; CPSF; CPSF-73
• Gene ID: 51692
• mRNA Refseq: NM_016207
• Protein Refseq: NP_057291
• MIM: 606029
• UniProt ID: Q9UKF6
• Chromosome Location: 2p25.1
• Pathway: Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem; Gene Expression, organism-specific biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; Processing of Capped Intronless Pre-mRNA, organism-specific biosystem; Processing of Intronless Pre-mRNAs, organism-specific biosystem; RNA Polymerase II Transcription, organism-specific biosystem; RNA Polymerase II Transcription Termination, organism-specific biosystem
• Function: 5-3 exonuclease activity; RNA binding; endoribonuclease activity; hydrolase activity; metal ion binding; protein binding