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Recombinant Human CTSE, GST-tagged

Cat.No.: CTSE-11685H
Product Overview: Recombinant Human CTSE protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.
Source: E.coli
Species: Human
Tag: GST
Protein length: 108-275a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: CTSE cathepsin E [ Homo sapiens ]
Official Symbol: CTSE
Synonyms: CTSE; cathepsin E; slow-moving proteinase; erythrocyte membrane aspartic proteinase; CATE;
Gene ID: 1510
mRNA Refseq: NM_001910
Protein Refseq: NP_001901
MIM: 116890
UniProt ID: P14091
Chromosome Location: 1q32.1
Pathway: Lysosome, organism-specific biosystem; Lysosome, conserved biosystem;
Function: aspartic-type endopeptidase activity; peptidase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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