Recombinant Human DCK, GST-tagged

• Cat.No.: DCK-11853H
• Product Overview: Recombinant Human DCK protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-260a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: DCK deoxycytidine kinase [ Homo sapiens ]
• Official Symbol: DCK
• Synonyms: DCK; deoxycytidine kinase; deoxynucleoside kinase; MGC117410; MGC138632
• Gene ID: 1633
• mRNA Refseq: NM_000788
• Protein Refseq: NP_000779
• MIM: 125450
• UniProt ID: P27707
• Chromosome Location: 4q13.3-q21.1
• Pathway: Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; Purine salvage, organism-specific biosystem
• Function: ATP binding; deoxycytidine kinase activity; drug binding; kinase activity; magnesium ion binding; nucleoside kinase activity; nucleotide binding; phosphotransferase activity, alcohol group as acceptor; protein homodimerization activity; pyrimidine deoxyri