Recombinant Human DSP, GST-tagged
Cat.No. : | DSP-12182H |
Product Overview : | Recombinant Human DSP protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-350a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | DSP desmoplakin [ Homo sapiens ] |
Official Symbol : | DSP |
Synonyms : | DSP; desmoplakin; desmoplakin (DPI, DPII); DPI; DPII; KPPS2; PPKS2; desmoplakin I; desmoplakin II; 250/210 kDa paraneoplastic pemphigus antigen; DP; |
Gene ID : | 1832 |
mRNA Refseq : | NM_001008844 |
Protein Refseq : | NP_001008844 |
MIM : | 125647 |
UniProt ID : | P15924 |
Chromosome Location : | 6pter-p21 |
Pathway : | Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cell adhesionproteins, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; |
Function : | protein binding; protein binding, bridging; structural constituent of cytoskeleton; structural molecule activity; |
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DSP-1381H | Recombinant Human DSP Protein (78-300 aa), His-tagged | +Inquiry |
DSP-1195H | Recombinant Human DSP Protein, His-SUMO-tagged | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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