Recombinant Human EIF4G1, His-tagged EIF4G1-12383H

Recombinant Human EIF4G1, His-tagged

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Recombinant Human EIF4G1, His-tagged

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Cat.No. : EIF4G1-12383H
Product Overview : Recombinant Human EIF4G1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description : The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.
Source : E.coli
Species : Human
Tag : His
Protein length : C-term-350a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 [ Homo sapiens ]
Official Symbol : EIF4G1
Synonyms : EIF4G1; eukaryotic translation initiation factor 4 gamma, 1; EIF4F, EIF4G; eukaryotic translation initiation factor 4 gamma 1; p220; EIF4-gamma; eIF-4-gamma 1; eucaryotic translation initiation factor 4G; P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1; DKFZp686A1451;
Gene ID : 1981
mRNA Refseq : NM_001194946
Protein Refseq : NP_001181875
MIM : 600495
UniProt ID : Q04637
Chromosome Location : 3q27-qter
Pathway : Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Deadenylation of mRNA, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Destabilization of mRNA by AUF1 (hnRNP D0), organism-specific biosystem;
Function : protein binding; translation factor activity, nucleic acid binding; translation initiation factor activity;

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