"EIF6" Related Products


Recombinant Human EIF6, GST-tagged

Cat.No.: EIF6-12391H
Product Overview: Recombinant Human EIF6 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene.
Source: E.coli
Species: Human
Tag: GST
Protein length: 1-245a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: EIF6 eukaryotic translation initiation factor 6 [ Homo sapiens ]
Official Symbol: EIF6
Synonyms: EIF6; eukaryotic translation initiation factor 6; EIF3A, integrin beta 4 binding protein , ITGB4BP; b(2)gcn; p27BBP; B4 integrin interactor; p27 beta-4 integrin-binding protein; eukaryotic translation initiation factor 3A; CAB; EIF3A; eIF-6; ITGB4BP; p27(BBP);
Gene ID: 3692
mRNA Refseq: NM_002212
Protein Refseq: NP_002203
MIM: 602912
UniProt ID: P56537
Chromosome Location: 20q11.2
Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Ribosome biogenesis in eukaryotes, organism-specific biosystem; Ribosome biogenesis in eukaryotes, conserved biosystem; Translation Factors, organism-specific biosystem;
Function: protein binding; ribosome binding; translation initiation factor activity;

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