Recombinant Human EIF6 protein, GST-tagged

• Cat.No.: EIF6-12391H
• Product Overview: Recombinant Human EIF6 protein(1-245 aa), fused with GST tag, was expressed in E.coli.

Specification

• Source: E.coli
• Species: Human
• Tag: GST
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 100mM GSH.
• Protein Length: 1-245 aa
• AA Sequence: MAVRASFENNCEIGCFAKLTNTYCL VAIGGSENFYSVFEGELSDTIPVVH ASIAGCRIIGRMCVGNRHGLLVPNN TTDQELQHIRNSLPDTVQIRRVEER LSALGNVTTCNDYVALVHPDLDRET EEILADVLKVEVFRQTVADQVLVGS YCVFSNQGGLVHPKTSIEDQDELSS LLQVPLVAGTVNRGSEVIAAGMVVN DWCAFCGLDTTSTELSVVESVFKLN EAQPSTIATSMRDSLIDSLT
• Purity: 85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.

Gene Information

• Gene Name: EIF6 eukaryotic translation initiation factor 6 [ Homo sapiens ]
• Official Symbol: EIF6
• Synonyms: EIF6; eukaryotic translation initiation factor 6; EIF3A, integrin beta 4 binding protein , ITGB4BP; b(2)gcn; p27BBP; B4 integrin interactor; p27 beta-4 integrin-binding protein; eukaryotic translation initiation factor 3A; CAB; EIF3A; eIF-6; ITGB4BP; p27(BBP)
• Gene ID: 3692
• mRNA Refseq: NM_002212
• Protein Refseq: NP_002203
• MIM: 602912
• UniProt ID: P56537

Reviews

08/25/2022

Dependable expertise in protein engineering, unmatched in quality.

12/11/2021

Invaluable protein-protein interaction assays, integral to our research.

01/28/2020

Swift protein sequencing, invaluable for protein identification.

Q&As

How does EIF6 influence stress responses in cells, particularly under conditions of nutrient deprivation or hypoxia?

EIF6 helps cells respond to stress, adapting protein synthesis under nutrient deprivation or hypoxic conditions.

How does EIF6 (Eukaryotic Translation Initiation Factor 6) regulate ribosome assembly and protein synthesis?

EIF6 is crucial for ribosome assembly and regulates the initiation of protein synthesis in eukaryotic cells.

What role does EIF6 play in controlling the translation of specific mRNAs in cells?

EIF6 plays a role in selectively controlling the translation of specific mRNA molecules.

How does EIF6 contribute to cellular growth and proliferation?

EIF6 contributes to cellular growth by facilitating efficient protein synthesis, necessary for cell proliferation.

How do alterations in EIF6 expression or activity affect the development of metabolic disorders?

Changes in EIF6 activity can impact metabolic processes, potentially leading to the development of metabolic disorders.

What is the impact of EIF6 dysregulation on cancer development and progression?

Dysregulation of EIF6 can lead to abnormal protein synthesis, contributing to cancer development and progression.

What are the mechanisms by which EIF6 modulates cell cycle progression and differentiation?

EIF6 influences cell cycle and differentiation by modulating the synthesis of key regulatory proteins.