Recombinant Human ENSA, GST-tagged ENSA-12464H

Recombinant Human ENSA, GST-tagged

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Recombinant Human ENSA, GST-tagged

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Cat.No. : ENSA-12464H
Product Overview : Recombinant Human ENSA protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description : The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-121a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : ENSA endosulfine alpha [ Homo sapiens ]
Official Symbol : ENSA
Synonyms : ENSA; endosulfine alpha; alpha-endosulfine; ARPP 19e; MGC4319; MGC8394; MGC78563; ARPP-19e;
Gene ID : 2029
mRNA Refseq : NM_004436
Protein Refseq : NP_004427
MIM : 603061
UniProt ID : O43768
Chromosome Location : 1q21.3
Function : ion channel inhibitor activity; phosphatase inhibitor activity; protein phosphatase 2A binding; protein phosphatase inhibitor activity; protein phosphatase type 2A regulator activity; receptor binding;

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