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Recombinant Human F12 protein, His-tagged

Cat.No. : F12-12617H
Product Overview : Recombinant Human F12 protein(316-615 aa), fused with His tag, was expressed in E.coli.
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Source : E.coli
Species : Human
Tag : His
Form : The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole.
Protein Length : 316-615 aa
AA Sequence : MPAQPAPPKPQPTTRTPPQSQTPGA LPAKREQPPSLTRNGPLSCGQRLRK SLSSMTRVVGGLVALRGAHPYIAAL YWGHSFCAGSLIAPCWVLTAAHCLQ DRPAPEDLTVVLGQERRNHSCEPCQ TLAVRSYRLHEAFSPVSYQHDLALL RLQEDADGSCALLSPYVQPVCLPSG AARPSETTLCQVAGWGHQFEGAEEY ASFLQEAQVPFLSLERCSAPDVHGS SILPGMLCAGFLEGGTDACQGDSGG PLVCEDQAAERRLTLQGIISWGSGC GDRNKPGVYTDVAYYLAWIREHTVS
Purity : 85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
Storage : Short-term storage: Store at 2-8°C for (1-2 weeks).
Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
Reconstitution : Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.
Gene Name : F12 coagulation factor XII (Hageman factor) [ Homo sapiens ]
Official Symbol : F12
Synonyms : F12; coagulation factor XII (Hageman factor); coagulation factor XII; Hageman factor; beta-factor XIIa part 1; beta-factor XIIa part 2; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain; HAF; HAE3; HAEX;
Gene ID : 2161
mRNA Refseq : NM_000505
Protein Refseq : NP_000496
MIM : 610619
UniProt ID : P00748

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does F12 play in thrombotic disorders? 05/30/2023

Abnormalities in F12 can lead to increased risk of thrombosis and related disorders.

How do genetic variations in the F12 gene affect coagulation and risk of bleeding or clotting disorders? 03/26/2022

Genetic mutations in F12 can result in either excessive bleeding or an increased tendency to form clots.

How does F12 interact with other components of the coagulation and fibrinolytic systems? 10/01/2021

F12 works in conjunction with other coagulation factors and proteins to regulate clot formation and breakdown.

What is the impact of altered F12 activity on inflammation and immune response? 04/28/2021

Altered F12 activity is associated with inflammation and can influence immune responses.

What potential therapeutic applications could arise from targeting F12 in clotting or inflammatory disorders? 12/29/2019

Targeting F12 offers potential in treating clotting disorders and reducing inflammation in certain conditions.

How does F12 activation initiate the intrinsic pathway of coagulation? 10/05/2018

Upon activation, F12 triggers a series of enzymatic reactions leading to clot formation.

What is the primary function of Factor XII (F12) in the blood coagulation cascade? 03/23/2017

Factor XII (F12) activates the intrinsic pathway of the coagulation cascade, crucial for blood clot formation.

Customer Reviews (3)

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06/23/2023

    Trustworthy data source. Valuable for our experiments.

    05/22/2022

      Accelerates research progress. Exceptional service provider.

      03/26/2018

        Enables data-driven decisions. A research necessity.

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