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Recombinant Human FANCL, His-tagged

Cat.No. : FANCL-12741H
Product Overview : Recombinant Human FANCL protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
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Description : The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms.
Source : E.coli
Species : Human
Tag : His
Protein length : 1-375a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : FANCL Fanconi anemia, complementation group L [ Homo sapiens ]
Official Symbol : FANCL
Synonyms : FANCL; Fanconi anemia, complementation group L; PHD finger protein 9 , PHF9; E3 ubiquitin-protein ligase FANCL; FAAP43; FLJ10335; Pog; PHD finger protein 9; fanconi anemia group L protein; fanconi anemia-associated polypeptide of 43 kDa; POG; PHF9;
Gene ID : 55120
mRNA Refseq : NM_001114636
Protein Refseq : NP_001108108
MIM : 608111
UniProt ID : Q9NW38
Chromosome Location : 2p16.1
Pathway : BARD1 signaling events, organism-specific biosystem; DNA Repair, organism-specific biosystem; FA core complex, organism-specific biosystem; Fanconi Anemia pathway, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Ubiquitin mediated proteolysis, organism-specific biosystem;
Function : ligase activity; metal ion binding; ubiquitin-protein ligase activity; ubiquitin-protein ligase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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