Recombinant Human FBLN1, GST-tagged
Cat.No. : | FBLN1-12764H |
Product Overview : | Recombinant Human FBLN1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3 end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-300a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | FBLN1 fibulin 1 [ Homo sapiens ] |
Official Symbol : | FBLN1 |
Synonyms : | FBLN1; fibulin 1; fibulin-1; FBLN; FIBL1; |
Gene ID : | 2192 |
mRNA Refseq : | NM_001996 |
Protein Refseq : | NP_001987 |
MIM : | 135820 |
UniProt ID : | P23142 |
Chromosome Location : | 22q13.31 |
Function : | calcium ion binding; extracellular matrix structural constituent; peptidase activator activity; |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionFBLN1 has been identified as a potential therapeutic target for the treatment of cardiovascular diseases due to its involvement in vascular function.
Genetic testing for FBLN1 mutations can be helpful in diagnosing certain connective tissue disorders.
The potential side effects of targeting FBLN1 as a therapeutic target are still under investigation and require further clinical trials.
FBLN1 has distinct roles and implications in clinical applications compared to other proteins, making it an important focus of research.
Mutations in the FBLN1 gene have been associated with developmental abnormalities in connective tissues, leading to connective tissue disorders such as Marfan syndrome and cutis laxa.
Customer Reviews (3)
Write a reviewThis partnership enhances research productivity while ensuring accurate and meaningful outcomes.
The manufacturer's commitment to maintaining stringent quality control measures guarantees that I can trust the protein's integrity and reliability throughout my experiments.
Its purity and stability ensure consistent and accurate results, making it an ideal tool for my research endeavors.
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