"FDPS" Related Products


Recombinant Human FDPS, GST-tagged

Cat.No.: FDPS-12834H
Product Overview: Recombinant Human FDPS protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
Source: E.coli
Species: Human
Tag: GST
Protein length: 68-419a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: FDPS farnesyl diphosphate synthase [ Homo sapiens ]
Official Symbol: FDPS
Synonyms: FDPS; farnesyl diphosphate synthase; farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; dimethylallyltranstransferase; geranyltranstransferase; FPP synthase; FPP synthetase; (2E,6E)-farnesyl diphosphate synthase; farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; FPS; FPPS;
Gene ID: 2224
mRNA Refseq: NM_001135821
Protein Refseq: NP_001129293
MIM: 134629
UniProt ID: P14324
Chromosome Location: 1q22
Pathway: Cholesterol Biosynthesis, organism-specific biosystem; Cholesterol biosynthesis, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem; Metabolic pathways, organism-specific biosystem;
Function: dimethylallyltranstransferase activity; geranyltranstransferase activity; metal ion binding; transferase activity;

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