Recombinant Human FGD1, GST-tagged
Cat.No. : | FGD1-12857H |
Product Overview : | Recombinant Human FGD1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | C-term-351a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | FGD1 FYVE, RhoGEF and PH domain containing 1 [ Homo sapiens ] |
Official Symbol : | FGD1 |
Synonyms : | FGD1; FYVE, RhoGEF and PH domain containing 1; faciogenital dysplasia (Aarskog Scott syndrome) , FGDY; FYVE, RhoGEF and PH domain-containing protein 1; ZFYVE3; rho/Rac GEF; faciogenital dysplasia 1 protein; zinc finger FYVE domain-containing protein 3; rho/Rac guanine nucleotide exchange factor FGD1; AAS; FGDY; MRXS16; |
Gene ID : | 2245 |
mRNA Refseq : | NM_004463 |
Protein Refseq : | NP_004454 |
MIM : | 300546 |
UniProt ID : | P98174 |
Chromosome Location : | Xp11.21 |
Pathway : | Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; NRAGE signals death through JNK, organism-specific biosystem; Regulation of Actin Cytoskeleton, organism-specific biosystem; Regulation of CDC42 activity, organism-specific biosystem; Regulation of actin cytoskeleton, organism-specific biosystem; |
Function : | Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; metal ion binding; small GTPase binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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