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Recombinant Human FOSL1, GST-tagged

Cat.No. : FOSL1-12965H
Product Overview : Recombinant Human FOSL1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-271a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : FOSL1 FOS-like antigen 1 [ Homo sapiens ]
Official Symbol : FOSL1
Synonyms : FOSL1; FOS-like antigen 1; fos-related antigen 1; fra 1; FOS-like antigen-1; FRA; FRA1; fra-1;
Gene ID : 8061
mRNA Refseq : NM_005438
Protein Refseq : NP_005429
MIM : 136515
UniProt ID : P15407
Chromosome Location : 11q13
Pathway : Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Osteoclast differentiation, organism-specific biosystem;
Function : protein binding; protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any ongoing studies investigating the role of FOSL1 in combination with other targeted therapies? 02/07/2022

Yes, preclinical studies and early-phase clinical trials are exploring the potential synergistic effects of combining FOSL1 inhibitors with other targeted therapies to enhance treatment efficacy.

How does the expression of FOSL1 correlate with patient survival in different cancers? 10/06/2021

High expression levels of FOSL1 have been associated with poor prognosis and shorter overall survival in various cancer patients.

How does the regulation of FOSL1 impact tumor microenvironment and metastasis? 05/06/2021

FOSL1 regulates the tumor microenvironment by promoting angiogenesis, immune evasion, and metastasis, thus contributing to cancer progression and spread.

What are the potential side effects of targeting FOSL1 in cancer treatment? 02/18/2017

Although the specific side effects may vary, common adverse effects of FOSL1-targeted therapies may include gastrointestinal disturbances, fatigue, and immunological reactions.

How does the dysregulation of FOSL1 contribute to tumorigenesis? 08/05/2016

Dysregulated FOSL1 expression can disrupt cellular homeostasis, leading to uncontrolled cell proliferation, evasion of cell death, and genomic instability, all of which contribute to tumorigenesis.

Customer Reviews (3)

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09/22/2022

    This reliable supply chain management assures that I have uninterrupted access to the protein, allowing me to plan and conduct my experiments without concern for availability issues.

    05/27/2019

      They ensure a reliable and consistent supply of FOSL1 protein, minimizing any potential disruptions in my experimental workflow.

      07/07/2016

        They ensure a reliable and consistent supply of FOSL1 protein, minimizing any potential disruptions in my experimental workflow.

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