Recombinant Human GABBR2, GST-tagged

• Cat.No.: GABBR2-13088H
• Product Overview: Recombinant Human GABBR2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 59-386a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 [ Homo sapiens ]
• Official Symbol: GABBR2
• Synonyms: GABBR2; gamma-aminobutyric acid (GABA) B receptor, 2; G protein coupled receptor 51 , GPR51; gamma-aminobutyric acid type B receptor subunit 2; GABABR2; GPRC3B; HG20; gb2; GABA-BR2; GABA-B-R2; GABA-B receptor 2; GABA-B receptor, R2 subunit; G protein-coupled receptor 51; G-protein coupled receptor 51; gamma-aminobutyric acid B receptor 2; GPR51; HRIHFB2099; FLJ36928
• Gene ID: 9568
• mRNA Refseq: NM_005458
• Protein Refseq: NP_005449
• MIM: 607340
• UniProt ID: O75899
• Chromosome Location: 9q22.1-q22.3
• Pathway: Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G protein gated Potassium channels, organism-specific biosystem; GABA B receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem
• Function: G-protein coupled GABA receptor activity; receptor activity; signal transducer activity