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Recombinant Human GLUD2, GST-tagged

Cat.No. : GLUD2-13320H
Product Overview : Recombinant Human GLUD2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism.
Source : E.coli
Species : Human
Tag : GST
Protein length : 207-558a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : GLUD2 glutamate dehydrogenase 2 [ Homo sapiens ]
Official Symbol : GLUD2
Synonyms : GLUD2; glutamate dehydrogenase 2; GLUDP1, glutamate dehydrogenase pseudogene 1; glutamate dehydrogenase 2, mitochondrial; GDH 2; glutamate dehydrogenase pseudogene 1; GDH2; GLUDP1;
Gene ID : 2747
mRNA Refseq : NM_012084
Protein Refseq : NP_036216
MIM : 300144
UniProt ID : P49448
Chromosome Location : Xq24-q25
Pathway : Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Arginine and proline metabolism, organism-specific biosystem; Arginine and proline metabolism, conserved biosystem; D-Glutamine and D-glutamate metabolism, organism-specific biosystem; D-Glutamine and D-glutamate metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem;
Function : ADP binding; GTP binding; glutamate dehydrogenase (NAD+) activity; glutamate dehydrogenase [NAD(P)+] activity; leucine binding; nucleotide binding; oxidoreductase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of altered GLUD2 activity on metabolic disorders? 04/06/2023

Altered GLUD2 activity can impact brain metabolism and contribute to metabolic and neurological disorders.

How do genetic variations in GLUD2 affect its enzymatic activity? 08/30/2020

Genetic mutations in GLUD2 can affect its function, potentially leading to neurological imbalances.

How does GLUD2 contribute to the regulation of neurotransmitter levels? 06/09/2019

It helps regulate neurotransmitter levels by converting glutamate to α-ketoglutarate.

What potential therapeutic applications arise from targeting GLUD2 in neurological conditions? 01/10/2019

Targeting GLUD2 could provide new treatments for conditions related to neurotransmitter imbalances.

What role does GLUD2 play in brain function and neurologic health? 10/04/2018

GLUD2 is important for brain function, influencing neurotransmitter balance and neuronal activity.

How does GLUD2 interact with other metabolic pathways in the brain? 03/26/2018

GLUD2 interacts with energy metabolism pathways in the brain, affecting neuronal energy supply.

What is the primary role of GLUD2 in amino acid metabolism? 03/29/2017

GLUD2, a glutamate dehydrogenase, is key in metabolizing glutamate, an important amino acid in the brain.

Customer Reviews (3)

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09/15/2022

    Consistency in quality. Supports our research consistently.

    10/07/2020

      Precision in analysis. Vital for our research goals.

      11/24/2018

        Expert service quality. Aids our research significantly.

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